Effect of halothane (narcothane) on intrauterine fetal development
Todorov, S.; Ovcharov, R.; Kostova, E.; Zaĭkov, K.
Eksperimentalna Meditsina i Morfologiia 18(2): 101-106
1979
ISSN/ISBN: 0367-0643 PMID: 467306 Document Number: 151001
The authors examined the effect of chalotane (narcotann ne-Spofa) on the development of a rat fetus. The rats were divided into groups and were narcotised for a period of 4 hours as well as 4.5 days. One of the group was narcotised from the 8 to the 13 day of gestation. Narcosis was made in chambers with dynamic inhalatory regimen at concentration of narcotane of 10 mg/m3 and 250 mg/m3. There was blastopathogenic effect of narcotane, manifested by an early resorption of nidaded ova, by nonspecific action on the fetus, which inhibited growth and development of the fetus and raised the mortality of the fetuses. The amount of estriol was diminished in mothers, treated with 250 mg/m3 of the drug.