Effect of halothane and halothane-nitrous oxide on hematocrit and plasma protein concentration in dog and monkey
Steffey, E.P.; Gillespie, J.R.; Berry, J.D.; Eger, E.I.; Schalm, O.W.
American Journal of Veterinary Research 37(8): 959-962
1976
ISSN/ISBN: 0002-9645 PMID: 821370 Document Number: 99922
Hematocrit and plasma protein concentration in healthy dogs and monkeys (Macaca arctoides) awake and anesthetized with halothane-oxygen and halothane-nitrous oxide oxygen were compared during conditions of spontaneous and controlled ventilation. Both hematocrit and plasma protein concentration decreased within 15 minutes following anesthetic induction. This decrease persisted throughout constant- or variable-depth anesthesia and did not vary appreciably with ventilation, anesthetic dose, or introduction of nitrous oxide. Plasma volume, determined by a dye dilution technique, concomitantly increased. This increase is compatible with the directional changes in hematocrit and plasma protein.