Heteroarylalkanoic acids with potential anti-inflammatory activity
Raffa, L.; Di Bella, M.; Ferrari, P.; Monzani, A.; Andrisano, M.G.; Baggio, G.
Il Farmaco; Edizione Scientifica 34(3): 199-210
1979
ISSN/ISBN: 0430-0920 PMID: 527708 Document Number: 149652
A series of (3-oxodihydro-1,2,4-benzothiadiazin-1,1-dioxide-3-yl)acetic acids [compounds of type (A)] and (1,2,4-benzothiadiazin-1,1-dioxide-3-yl)oxyacetic acids [compounds of type (B)] were synthesised and tested for antiinflammatory activity. Preliminary tests showed certain compounds to have a significant level of antiinflammatory activity in rat paw edema induced by carrageenan. It was found that the antiinflammatory activity of this series of compounds depends on the nature, number and position of the substituents on the benzene ring.