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Effect of Nocardia rubra cell-wall skeleton on the induction of lung cancer in ACI/N rats

Namba, M.; Yoshimoto, T.; Ogura, T.; Hirao, F.; Azuma, I.; Yamamura, Y.

Gan 70(1): 55-62

1979

ISSN/ISBN: 0016-450X
PMID: 446976
Document Number: 149422
In ACI/N rats administration of oil-attached N. rubra cell-wall skeleton (CWS) was evaluated for its effect on lung cancer induction. Lung cancers were induced by 15 weekly intratracheal instillations of 3 mg benzo pyrene with 3 mg ferric oxide. After the 10th instillation of the carcinogen, rats received 7 s.c. injections of 100 .mu.g of N. rubra-CSW at 2 wk intervals. In the observation period of 56 wk, the cumulative incidence of lung cancer was 71.4% in the control group and 48.0% in the N. rubra-CWS treated group. The latent period of tumor induction was prolonged in the group treated with N. rubra-CWS.

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