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Activation of peritoneal macrophages by oil-attached cell-wall skeleton of BCG and Nocardia rubra

Masuno, T.; Ito, M.; Ogura, T.; Hirao, F.; Yamawaki, M.; Azuma, I.; Yamamura, Y.

Gan 70(2): 223-227

1979

ISSN/ISBN: 0016-450X
PMID: 381089
Document Number: 145431
The effect of oil-attached cell-wall skeletons of BCG (BCG-CWS) and N. rubra (N. rubra-CWS) on cells. A single i.p. injecton of BCG-CWS or N. rubra-CWS in mice resulted in accumulation of a large number of macrophages in the peritoneal cavity. They demonstrated, in vitro, a significant cytostatic effect on target cells and an increase in phagocytic activity and uptake of 2-dG. One of the underlying mechanisms for the antitumor activity of BCG-CWS and N. rubra-CWS is possibly the activated macrophage-mediated system.

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