Ketotifen, a selective histamine liberator
Gushchin, I.S.; Deriugin, I.L.
Biulleten' Eksperimental'noi Biologii i Meditsiny 88(11): 597-599
1979
ISSN/ISBN: 0365-9615 PMID: 94270 Document Number: 149334
Ketotifen-induced histamine release from isolated rat mast cells is inhibited under conditions of ATP content depletion in the mast cells. The histamine release is a temperature-dependent process and is blocked at a low temperature. It is concluded that ketotifen is a selective histamine liberator. Time course of ketotifen-induced histamine release corresponds with the process of partial cellular uptake of histamine released.