A review of the animal pharmacology of ranitidine--a new, selective histamine H2-antagonist

Brittain, R.T.; Daly, M.J.

Scandinavian Journal of Gastroenterology. Suppl 69: 1-9

1981


ISSN/ISBN: 0085-5928
PMID: 6119769
Document Number: 178047
The animal pharmacology and metabolism of ranitidine have been reviewed. Experiments using guinea-pig isolated right atrium and ileum preparations have shown that ranitidine is a selective, potent, and competitive histamine H2-receptor antagonist. In the conscious dog gastric acid secretion induced by histamine, pentagastrin, bethanechol and food was inhibited by ranitidine at doses 4 to 12 times lower than equi-effective doses of cimetidine. Ranitidine inhibited the formation of aspirin-induced gastric lesions, both in the presence and absence of gastric acid. Unlike cimetidine, ranitidine neither possessed anti-androgenic activity, nor did it inhibit the mixed function oxygenase metabolizing enzyme system in the liver. Ranitidine has been recommended for clinical trial in the treatment of peptic ulcer disease.

Document emailed within 1 workday
Secure & encrypted payments