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A review of the animal pharmacology of ranitidine--a new, selective histamine H2-antagonist

Brittain, R.T.; Daly, M.J.

Scandinavian Journal of Gastroenterology. Suppl 69: 1-9

1981

ISSN/ISBN: 0085-5928
PMID: 6119769
Document Number: 178047
The animal pharmacology and metabolism of ranitidine have been reviewed. Experiments using guinea-pig isolated right atrium and ileum preparations have shown that ranitidine is a selective, potent, and competitive histamine H2-receptor antagonist. In the conscious dog gastric acid secretion induced by histamine, pentagastrin, bethanechol and food was inhibited by ranitidine at doses 4 to 12 times lower than equi-effective doses of cimetidine. Ranitidine inhibited the formation of aspirin-induced gastric lesions, both in the presence and absence of gastric acid. Unlike cimetidine, ranitidine neither possessed anti-androgenic activity, nor did it inhibit the mixed function oxygenase metabolizing enzyme system in the liver. Ranitidine has been recommended for clinical trial in the treatment of peptic ulcer disease.

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Poizot, A.; Dumez, D.; Ferrandon, P.; Lefournier, C.; Michel, A.; Armstrong, J.M. 1986: Animal pharmacology of the selective histamine H1-receptor antagonist tazifylline Arzneimittel-Forschung 36(4): 695-702
Cieślewicz, G.; Gondorowicz, K.; Grzelewska-Rzymowska, I.; Rozniecki, J. 1995: Effect of loratadine, selective antagonist of histamine H1 receptors, on histamine-induced bronchoconstriction Pneumonologia i Alergologia Polska 63(5-6): 281-285
Klima, P. 1984: Experiences with the histamine-H2-receptor antagonist ranitidine in the prevention of stress ulcers Wiener Medizinische Wochenschrift 134(15-16): 369-373
Katz, L.B.; Scott, C.K.; Shriver, D.A. 1986: Pharmacological comparison of ORF 17910, a potent, long-acting histamine H2-receptor antagonist, to cimetidine and ranitidine Journal of Pharmacology and Experimental Therapeutics 238(2): 587-593
Engelhardt, G. 1975: On the pharmacology of 9,10-dihydro-10-(1-methyl-4-piperidylidene)-9-anthrol (WA 335), a histamine and serotonin antagonist Arzneimittel-Forschung 25(11): 1723-1737
Cieślewicz, G.; Gondorowicz, K.; Grzelewska-Rzymowska, I.; Rozniecki, J.; Wojciechowska, B. 1992: Effect of loratadine--selective antagonist of histamine (H1) receptor--on allergen-induced bronchoconstriction in atopic asthmatics Pneumonologia i Alergologia Polska 60(11-12): 11-15
Roychoudhury, M.; Kulkarni, S.K. 1997: Antianxiety profile of ondansetron, a selective 5-HT3 antagonist, in a novel animal model Methods and Findings in Experimental and Clinical Pharmacology 19(2): 107-111
Berner, B.D.; Conner, C.S.; Sawyer, D.R.; Siepler, J.K. 1983: Ranitidine: a new H2-receptor antagonist Clinical Pharmacy 1(6): 499-509
Konturek, S.J. 1982: Pharmacology and clinical use of ranitidine Mount Sinai Journal of Medicine new York 49(5): 370-382
Dal Negro, R.; Pomari, C.; Zoccatelli, O.; Trevisan, F.; Carloni, C.; Turco, P. 1984: Pharmacokinetics of theophylline and the H2-antagonist drugs cimetidine and ranitidine International Journal of Clinical Pharmacology Therapy and Toxicology 22(4): 221-226
Kamada, T.; Kusunoki, H.; Manabe, N.; Shiotani, A.; Hata, J.; Haruma, K. 2007: Histamine-2 receptor antagonist Nihon Rinsho. Japanese Journal of Clinical Medicine 65(10): 1835-1840
Tracqui, A.; Kintz, P.; Mangin, P.; Lugnier, A.A.; Chaumont, A.J. 1988: A new rapid HPLC assay for the simultaneous determination of two histamine H2-receptor antagonists, cimetidine and ranitidine, in human plasma Journal de Toxicologie Clinique et Experimentale 8(6): 387-394
Morita, T.; Fukuda, T.; Sukamoto, T.; Tajima, S.; Sato, I.; Ikeda, Y.; Kanazawa, T.; Hamada, Y.; Morimoto, Y.; Kitamura, H.; Kawakami, K.; Ito, K.; Nose, T. 1982: General pharmacology of KB-944, a new calcium antagonist Arzneimittel-Forschung 32(9): 1060-1068
Mills, J.G.; Wood, J.R. 1989: The pharmacology of histamine H2-receptor antagonists Methods and Findings in Experimental and Clinical Pharmacology 11(Suppl 1): 87-95
Cheret, A.M.; Pignal, F.; Lewin, M.J. 1981: Effects of H2-receptor antagonists cimetidine, ranitidine, and ICi 125,211 on histamine-stimulated adenylate cyclase activity in guinea pig gastric mucosa Molecular Pharmacology 20(2): 326-330
Krivonkin, K.I.; Belousov, I.B. 1991: Clinical pharmacology of nisoldipine, a new calcium antagonist Kardiologiia 31(9): 100-105
Wyllie, J.H. 1978: Histamine H2-receptor antagonist in treatment of peptic ulcer Postgraduate Medicine 63(4): 91
Brimblecombe, R.W.; Duncan, W.A.; Durant, G.J.; Emmett, J.C.; Ganellin, C.R.; Leslie, G.B.; Parsons, M.E. 1978: Characterization and development of cimetidine as a histamine H2-receptor antagonist Gastroenterology 74(2 Part 2): 339-347
Meyer, B.H.; Müller, F.O.; Badian, M.; Hundt, H.K.; Joubert, A.L.; Luus, H.G. 1988: Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics South African Medical Journal 73(7): 421-423
Cohen, M.L.; Fuller, R.W.; Kurz, K.D.; Parli, C.J.; Mason, N.R.; Meyers, D.B.; Smallwood, J.K.; Toomey, R.E. 1988: Preclinical pharmacology of a new serotonergic receptor antagonist, LY281067 Journal of Pharmacology and Experimental Therapeutics 244(1): 106-112