Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics
Meyer, B.H.; Müller, F.O.; Badian, M.; Hundt, H.K.; Joubert, A.L.; Luus, H.G.
South African Medical Journal 73(7): 421-423
1988
ISSN/ISBN: 0256-9574 PMID: 2895963 Document Number: 308321
A double-blind cross-over study of the effects of HOE 760 (histamine H2-receptor blocker) on diazepam pharmacokinetics was conducted in 12 healthy men. HOE 760 or placebo was given daily for 12 days and, after a wash-out period of 9 days, the alternate medication was given for 12 days. Diazepam 10 mg was given intravenously on day 6 of each of the 12-day periods. Blood was taken up to 1 week after the diazepam injections for assay of diazepam and desmethyldiazepam. The co-administration of HOE 760 did not affect the pharmacokinetics of diazepam and desmethyldiazepam.