Specific immunotherapy stimulates the binding of histamine H2 receptor antagonist by lymphocytes
Zak-Nejmark, T.; Małolepszy, J.; Nadobna, G.; Kuczyńska-Sekieta, K.; Marczyńska-Sarul, E.; Jutel, M.
Archivum Immunologiae et Therapiae Experimentalis 40(2): 113-116
1992
ISSN/ISBN: 0004-069X PMID: 1299167 Document Number: 400166
The binding of antagonists of histamine receptors H-1 (promethazine) and H-2 (ranitidine) by peripheral blood lymphocytes from pollinotics was determined before and after the course of immunotherapy. We found that lymphocytes from atopic subjects showed significant decrease in the binding of H-2 receptor antagonist as compared to control subjects. Specific immunotherapy induced statistically significant increase in H-2 receptor antagonist binding, which correlated with the improvement of clinical symptoms.