Accelerated granuloma formation in adjuvant-induced arthritic rats and its modification by antirheumatic drugs
Nakamura, H.; Shimizu, M.
Journal of Pharmacology and Experimental Therapeutics 211(1): 20-25
1979
ISSN/ISBN: 0022-3565 PMID: 490318 Document Number: 147638
Granuloma formation in rats which received an intradermal inoculation of adjuvant (Mycobacterium tuberculosis, 0.6 mg/tail) (adjuvant rats) was studied felt-pellet implantation. Dry wt of granulation tissue formed around the felt-pellet implanted on the 21st day after adjuvant inoculation was significantly heavier (30-40%) than that in intact rats. The acceleration phenomenon was seen when the felt-pellet was implanted 3-63 days but not immediately or 245 days after the adjuvant. There was no clear correlation between dry granuloma wt and arthritic severity. Excess production was completely prevented by treatment with cyclophosphamide (6 mg/kg/day p.o.) for the first 2 or 3 wk but not for the 1st wk nor during the 3rd wk after the adjuvant alone when the felt-pellet was implanted at the end of the 3rd wk. Granuloma formation in intact rats was not inhibited by cyclophosphamide. Granuloma formation in the adjuvant rat was partly but significantly inhibited by oral treatment with prednisolone or by high doses of indomethacin, flufenamic acid, phenylbutazone, tolmetin and ibuprofen for 5 days from the day of implantation. Granuloma formation in the adjuvant rat is qualitatively different from that in intact rats.