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Molecular mechanism of general anesthesia: II. Spin label studies on synaptic membranes

Mazzanti, L.; Curatola, G.; Zolese, G.; Bertoli, E.; Lenaz, G.

Bollettino della Societa Italiana di Biologia Sperimentale 55(6): 506-510

1979

ISSN/ISBN: 0037-8771
PMID: 233072
Document Number: 147358
In this communication we report the effects of general anesthetics on the mobility and order of spin labeled stearic acid derivatives in synaptic membranes and in bilayers formed from the lipids extracted therefrom. The anesthetics studied abolish the immobilization induced by synaptic membrane proteins on the membrane lipids : this effect, observed particularly in the bilayer core, is interpreted as a labilization of lipid-protein interactions induced by anesthetics.

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