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Comparison of the Level of Magnesium during Maintenance between 2 Gram and 1 Gram per Hour Infusion in Overweight Mothers with Preeclampsia

Kitiyodom, S.

Journal of the Medical Association of Thailand 99(Suppl 7): S133-S137

2016

ISSN/ISBN: 0125-2208
PMID: 29901967
Document Number: 14679
Magnesium sulfate is most effective for prevention and treatment of convulsions among preeclampsia women. The therapeutic level of magnesium at 4.8 to 8.4 mg/dL and the overdose of magnesium may be fatal. In Maharat Nakhon Ratchasima Hospital, intravenous magnesium sulfate is used with the starting dose of 4 grams followed by 1 gram per hour for symptom control. However, between 2012 and 2013, in Maharat Nakhon Ratchasima Hospital, 14 cases of eclampsia To compare the success rates of yielding the standard therapeutic level of magnesium among overweight mothers with preeclampsia after receiving 1 gram and 2 gram per hour of magnesium sulfate maintenance infusion. This study was a randomized controlled trial study. The 38 overweight mothers (BMI ≥25 kg/m(2)) who The body mass index of the experimental and the control groups were 33.5±6.84 and 33.7±6.09 kg/m(2), respectively. No difference in the basic characteristics between the two groups was observed. The rate of achievement of the therapeutic level of magnesium in the experimental group was higher than that of the control group both before delivery (52.6% vs. 15.8%, respectively, RR 3.3 (95% CI 1.08-10.24)) and after delivery (84.2 % vs. 42.1%, respectively, RR 2.0, 95% CI: (1.14-3.51)). Neither the overdose of magnesium nor convulsions were found in either group. The dose of magnesium in the control group was raised to 1.5 gram per hour in four patients and 2 grams per hour in seven patients to achieve the therapeutic level after delivery. The therapeutic level of magnesium in overweight mothers with preeclampsia could be more frequently accessed before and after delivery with the dose of 2 grams per hour of magnesium sulfate infusion. No overdose of magnesium was observed. This fact would be used to improve the guideline of preeclampsia patient care.

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