The absorption and excretion rates of a new pyrido[1,2-a] pyrimidine derivative (Chinoin 123) in rats
Szentmiklósi, P.; Marton, S.; Kovács, M.; Gyarmati, L.
Die Pharmazie 34(9): 551-556
1979
ISSN/ISBN: 0031-7144 PMID: 542489 Document Number: 146556
The metabolism and absorption of a potential new drug, Chinoin 123, having an antiatherogenic effect, were studied in rats. Using different methods it was confirmed that the main metabolite of the drug is a free acid form, formed by ester hydrolysis. In Sartorius Resorption Model only the gastric absorption was confirmed and calculated. In vivo experiments in rats showed rather good absorption. The blood and urine concentrations of the drug were determined.
Document emailed within 1 workday
Related Documents
Kozlovskaia, M.M.; Inozemtsev, A.N.; Nikitin, S.V.; Gochmuradov, A.G.; Iakushev, R.A.; Chabak-Gorbach, R. 1995: Comparison of neurotropic and stress-protective properties of piracetam and the derivative pyrido]1,2-a]pyrimidine Biulleten' Eksperimental'noi Biologii i Meditsiny 119(3): 299-301Gyires, K.; Fürst, S.; Miklya, I.; Budavari, I.; Knoll, J. 1985: Analysis of the analgesic and anti-inflammatory effects of rimazolium, a pyrido-pyrimidine derivative, compared with that of prostaglandin synthesis inhibitors and morphine Drugs under Experimental and Clinical Research 11(8): 493-500
Di Braccio, M.; Roma, G.; Mazzei, M.; Balbi, A.; Schiantarelli, P.; Cadel, S.; Bongrani, S. 1988: Derivatives of pyrimidine 1,2-condensate. IV. Synthesis and pharmacological properties of the N,N-disubstituted 4-amino-2H-pyrido(1,2-a)pyrimidin- 2-ones and 2-amino-4H-pyrido(1,2-a)pyrmidin-4-ones Il Farmaco; Edizione Scientifica 43(9): 705-723
Monge, A.; Martinez-Merino, V.; Sanmartin, C.; Ochoa, M.C.; Fernandez-Alvarez, E. 1990: New 5H-[1,3]thiazolo[3,2-a]pyrido[3,2-e]pyrimidine derivatives as diuretics Arzneimittel-Forschung 40(12): 1349-1352
Prakash, L.; Shaihla; Malik, S.; Mital, R.L. 1989: Synthesis and antibacterial activity of some new pyrido[2,3-d]pyrimidine derivatives Die Pharmazie 44(7): 490
Winter, M.; Simon, G.; Szüts, T.; Vargay, Z. 1978: Absorption and biliary excretion of NoSpa in rats Acta Pharmaceutica Hungarica 48 Suppl: 13-15
Miller, W.J. 1973: Dynamics of absorption rates, endogenous excretion, tissue turnover, and homeostatic control mechanisms of zinc, cadmium, manganese, and nickel in ruminants Federation Proceedings 32(8): 1915-1920
Srivastava, V.M.; Roy, T.K. 1981: Absorption, distribution & excretion of centperazine in male rats Indian Journal of Experimental Biology 19(8): 785-786
Rózsa, I.; Kapui, Z.; Szécsi, T.; Hermecz, I.; Blaskó, G. 1989: Synthesis of prostacyclin and thromboxane A2 by rat gastric mucosa. Comparison of 1,6-dimethyl-4-oxo-1,6,7,8,9,9a-hexahydro-4H-pyrido (1,1-a)-pyrimidine-3-carboxamide and cimetidine Arzneimittel-Forschung 39(6): 686-689
Li, D.; Zhu, M.; Yang, X.Y.; Wang, Z.Y.; Li, L.; Yang, S.Y.; Chu, Q.M.; Chen, X.N. 1988: Absorption, distribution and excretion of gallanilide in rats and bioavailability in rabbits Zhongguo Yao Li Xue Bao 9(2): 182-185
Shafii, A.; Chowdhury, J.R.; Das, K.M. 1982: Absorption, enterohepatic circulation, and excretion of 5-aminosalicylic acid in rats American Journal of Gastroenterology 77(5): 297-299
Fujii, T.; Matsumoto, S.; Amejima, H.; Hatoyama, T.; Nakao, M.; Kagemoto, A.; Tanaka, K.; Miyazaki, H. 1994: Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats Arzneimittel-Forschung 44(4): 527-538
Nowicka, A.; Prussak, T.; Szukalski, B. 1975: Absorption, distribution in tissues and routes of excretion of preparation IF-ROM-196 administered to rats orally Materia Medica Polona. Polish Journal of Medicine and Pharmacy 7(4): 304-307
Queisnerová, M.; Nĕmecek, O. 1971: Absorption, distribution and excretion rate in diphenyldioxypyrazolidine drugs -14 C-kebuzon and 14 C- trimetazon- in rats Ceskoslovenska Farmacie 20(2): 55-59
Sakai, A.; Iwasaki, M.; Suzuki, T.; Morishita, M.; Muranishi, S. 1988: Studies on the metabolic fate of 14C-rokitamycin. Absorption, distribution, metabolism and excretion in infant rats Japanese Journal of Antibiotics 41(7): 797-808
Kobayashi, S.; Kyui, S.; Yoshida, T.; Nagakura, A.; Oiwa, Y.; Matsumura, R.; Kohei, H. 1981: Absorption, distribution and excretion of 14C-pirenzepine in rats. Accumulation characteristics after multiple dose regimen Arzneimittel-Forschung 31(4): 679-690
Kowaluk, E.A.; Mikusa, J.; Wismer, C.T.; Zhu, C.Z.; Schweitzer, E.; Lynch, J.J.; Lee, C.H.; Jiang, M.; Bhagwat, S.S.; Gomtsyan, A.; McKie, J.; Cox, B.F.; Polakowski, J.; Reinhart, G.; Williams, M.; Jarvis, M.F. 2000: ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. in vivo characterization in the rat Journal of Pharmacology and Experimental Therapeutics 295(3): 1165-1174
Takamatsu, N.; Nishio, A.; Nagata, S.; Matsumoto, J.; Kamimura, Y.; Miyamoto, A.; Ishiguro, S. 2001: Decreased absorption and retention rates of magnesium in the rats fed on spinach-supplemented diets: possible explanations Magnesium Research 14(4): 247-256
Suzuki, T.; Serizawa, K.; Somiya, Y.; Shirai, M.; Endo, S.; Morishita, M. 1987: Studies on the metabolic fate of isepamicin sulfate (HAPA-B). I. Absorption, distribution, metabolism and excretion in rats Japanese Journal of Antibiotics 40(1): 188-201
Goldaniga, G.C.; Pianezzola, E.; Valzelli, G. 1974: Absorption, excretion and metabolism of a new analgesic and anti-inflammatory drug K 4277 in rats, guinea pigs, rabbits and dogs Arzneimittel-Forschung 24(10): 1603-1606