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Comparison of neurotropic and stress-protective properties of piracetam and the derivative pyrido]1,2-a]pyrimidine

Kozlovskaia, M.M.; Inozemtsev, A.N.; Nikitin, S.V.; Gochmuradov, A.G.; Iakushev, R.A.; Chabak-Gorbach, R.

Biulleten' Eksperimental'noi Biologii i Meditsiny 119(3): 299-301

1995

ISSN/ISBN: 0365-9615
PMID: 7795202
Document Number: 453603
Experiments with albino rats showed that a new pyrido(1,2-a)pyrimidine derivative exhibited psychostimulant activity during the elaboration of avoiding response in a shuttle chamber. This effect was manifested as acceleration of learning. It was also shown that the compound possessed stress-protective activity in a model of acute emotional stress caused by disturbance of the adequacy of the cause-result relationships in experimental environment. This affect was similar of that of piracetam.

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