Potency testing of pertussis immunoglobulins, relationship between neutralisation test and agglutination test
Schneider, W.; Sabin, S.; Schwanig, M.
Developments in Biological Standardization 44: 125-128
1979
ISSN/ISBN: 0301-5149 PMID: 575633 Document Number: 146549
Neutralisation tests were done with pertussis immunoglobulins and immunosera in which mice were immunised by intraperitoneal injection and challenged 4 hours later by intracerebral injection. The results of the neutralisation tests were compared with those of the agglutination tests done with the same preparations. For 2 pertussis immunoglobulins a correlation was found between the results of both tests, but generally no correlation exists between the agglutinating activity and the protective value of the preparations. There is a more than 100-fold difference in their relationship. Therefore a neutralisation test should be used for potency testing of pertussis immunoglobulins.
Document emailed within 1 workday
Related Documents
Van der Ark, A.; van Straaten-van de Kappelle, I.; Hendriksen, C.; van de Donk, H. 1996: Pertussis serological potency test as an alternatively to the intracerebral mouse protection test Developments in Biological Standardization 86: 271-281Ulisko, I.N.; Landsman, N.M.; Golshmid, V.K.; Romanenko, E.E. 1977: Highly specific agglutinating O- and OK-immunoglobulins for identification of Escherichia in the agglutination test on glass Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 9: 36-40
Luick, K.; Gottschaldt, J.; Schulze, F.; Werner, E.; Erler, W.; Borrmann, E. 2002: The use of the toxin binding inhibition test for potency testing of Clostridium novyi type B alpha toxoid vaccines Deutsche Tierärztliche Wochenschrift 109(4): 178-182
Andiva, S.; Yera, H.; Haeghebaert, S.; Tourte-Schaefer, C.; Magnaval, J.F.; Dupouy-Camet, J. 2002: Comparative evaluation of a latex agglutination test, two Elisa tests and a Western blot test for the serodiagnosis of human trichinellosis Annales de Biologie Clinique 60(1): 79-83
Larbaigt, G.; Moulin, J.; Souvras, M.; Gibelin, N.; Beranger, G. 1981: Potency test of killed polio vaccines. Statistical analysis of test on chicken and preliminary results in combination with ELISA D-antigen determinations Developments in Biological Standardization 47: 113-118
Kast, R.E.; Bjerrum, O.W. 1978: Lymphocyte agglutination blocking test. a pilot study of a new simple in vitro blood test for demonstration of cancer and tissue destruction Ugeskrift for Laeger 140(42): 2572-2575
Hayashi, S.; Kiyokawa, T.; Aochi, H.; Nagamine, K.; Oshida, M.; Tomiyama, Y.; Kurata, Y. 1994: Detection of anti-neutrophil antibodies by enzyme linked immunosorbent assay--comparison of results obtained by ELISA with those by leukocyte agglutination test and granulocyte cytotoxicity test Rinsho Byori. Japanese Journal of Clinical Pathology 42(5): 527-533
Zschöck, M.; Schneider, W.; Hamann, H.P.; Mumme, J.; Schliesser, T. 1988: Detection of thermolabile enterotoxins of Escherichia coli with the Vero cell test, ganglioside (GM1)-enzyme-linked immunosorbent assay and latex agglutination test--a comparative study Berliner und Munchener Tierarztliche Wochenschrift 101(7): 245-247
Wada, H.G.; Chang, D.D.; Rippe, D.F.; Williams, J.; Minnich, L.; Witheiler, A.P. 1981: Evaluation of the rubesure test kits rubella hem agglutination inhibition test kits using human group o erythrocyte Abstracts of the Annual Meeting of the American Society for Microbiology 81: 289
Ryu, E.; Hasegawa, A.; Saegusa, S.; Ichiki, H. 1974: An investigation of canine leptospiral antibodies in Tokyo and Yokohama. Comparison of Canine Positive rates between rapid microscopic agglutination test and Schüffner-Mochtar test International Journal of Zoonoses 1(2): 82-90
Snyder, H.; Yeldandi, V.V.; Prem Kumar, G.; Liao, C.; Lakshmi, V.; Gandham, S.R.; Muppudi, U.; Oruganti, G.; Schneider, J.A. 2012: Field-based video pre-test counseling, oral testing, and telephonic post-test counseling: implementation of an HIV field testing package among high-risk Indian men Aids Education and Prevention: Official Publication of the International Society for Aids Education 24(4): 309-326
Menzel, G.; Hänsel, H. 1977: Methods for testing the sensitivity of pathogenic microorganisms: leaflet test or scatter test? Zeitschrift für die Gesamte Hygiene und ihre Grenzgebiete 23(9): 675-677
Peck, R.B.; Lim, J.M.; van Rooyen, H.; Mukoma, W.; Chepuka, L.; Bansil, P.; Knight, L.C.; Muturi, N.; Chirwa, E.; Lee, A.M.; Wellhausen, J.D.; Tulloch, O.; Taegtmeyer, M. 2014: What should the ideal HIV self-test look like? a usability study of test prototypes in unsupervised HIV self-testing in Kenya, Malawi, and South Africa Aids and Behavior 18(Suppl 4): S422-S432
Hsu, M.M.; Lo, R.J.; Lynn, T.C.; Hsieh, T.; Tu, S.M. 1975: Cellular immunity in nasopharyngeal carcinoma. I. Relationship between purified protein derivative test and leukocyte migration test Journal of the Formosan Medical Association 74(8): 517-524
Kanoh, S.; Kawasaki, H. 1980: Studies on the relationship between the pyrogen test and limulus test Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 98: 76-80
Mills, K.H.; Brady, M.; Ryan, E.; Mahon, B.P. 1998: A respiratory challenge model for infection with Bordetella pertussis: application in the assessment of pertussis vaccine potency and in defining the mechanism of protective immunity Developments in Biological Standardization 95: 31-41
Schraderolms, B.; Seibel, W.; Pfeilsticker, K. 1986: Analytische, teigrheologische und backtechnische Studien zur Optimierung des Weizen-Backversuches, Rapid-Mix-Test - Etude bromatologique, rhéologique et technologique d'optimisation du «Rapid-Mix-Test» de panification du blé. II. Travaux préliminaires pour l'optimisation des essais de panification par le «Rapid-mix-test» - Analytical, dough rheological and baking studies of optimizing the wheat flour baking test, Rapid-Mix-Test. 2. Part : Procedure of the optimized Rapid-Mix-Test Getreide, Mehl und Brot (1972) 40(4): 116-118
Schraderolms, B.; Seibel, W.; Pfeilsticker, K. 1986: Analytische, teigrheologische und backtechnische Studien zur Optimierung des Weizen-Backversuches, Rapid-Mix-Test - Etude bromatologique, rhéologique et technologique d'optimisation du «Rapid-Mix-Test» de panification du blé. II. Travaux préliminaires pour l'optimisation des essais de panification par le «Rapid-mix-test» - Analytical, dough rheological and baking studies of optimizing the wheat flour baking test, Rapid-Mix-Test. 2. Part : Procedure of the optimized Rapid-Mix-Test Getreide, Mehl und Brot (1972) 40(4): 116-118
Cappa, D.F.; García, G.C.; Secchi, J.D.; Maddigan, M.E. 2014: The relationship between an athlete's maximal aerobic speed determined in a laboratory and their final speed reached during a field test (UNCa Test) Journal of Sports Medicine and Physical Fitness 54(4): 424-431
Kawasaki, H.; Kanoh, S. 1982: Studies on the relationship between pyrogen test and Limulus test. III. Effect of heat treatment on the Limulus gelation activity of LPS in glucose solutions Eisei Shikenjo Hokoku. Bulletin of National Institute of Hygienic Sciences 100: 120-124