Modifications of the synaptosomal level of gamma-aminobutyric acid during convulsions provoked by pentamethylenetetrazol
Gonzalez Rios, F.; Gonnard, P.; Bloch-Tardy, M.; Wegmann, R.
Cellular and Molecular Biology Including Cyto-Enzymology 25(3): 191-194
1979
ISSN/ISBN: 0145-5680 PMID: 544016 Document Number: 145458
Variations in the GABA level and the L-glutamate decarboxylase (GAD) activity in the synaptosomes prepared from 5 zones of the CNS of the rat during convulsions provoked by i.p. injections of pentetrazol were analyzed. Assays were done on homogenates of the whole brain and of each of the 5 regions of the CNS. The modifications in the level of GABA were observed only at the synaptosomal level, without being attributed to variations in the synthesis of the GABA through GAD.