Agonism and antagonism of gamma-aminobutyric acid

Steward, E.G.; Borthwick, P.W.; Clarke, G.R.; Warner, D.; Steward, E.G; Borthwick, P.W; Clarke, G.R; Warner, D

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Agonism and antagonism of gamma-aminobutyric acid

Steward, E.G.; Borthwick, P.W.; Clarke, G.R.; Warner, D.

Nature 256(5518): 600-602

1975

ISSN/ISBN: 0028-0836

PMID: 1165779

Document Number: 85054

Evidence that (+)bicuculline (BIC) is a competitive antagonist of the central inhibitory transmitter γ-aminobutyric acid (GABA) is based1 mainly on apparent similarities between the molecular structures of BIC, Gaba and agonists of GABA. Until recently, there has not been any explanation of the differing potencies of the agonists, or why Bic is an antagonist instead.