Hormonal control of rat liver regeneration
Leffert, H.L.; Koch, K.S.; Moran, T.; Rubalcava, B.
Gastroenterology 76(6): 1470-1482
1979
ISSN/ISBN: 0016-5085 PMID: 220134 Document Number: 145032
One problem of animal cell growth regulation which has generated tremendous controversy and speculation has been the search for hepatotrophic factors. Eagerly sought because of their postulated role in regulating liver regeneration, a rapid but transient proliferative process extensively studied in the rat following partial hepatectomy, it seemed reasonable to expect that by characterizing these substances, and their physiological actions upon the liver, a precise explanation of fundamental regulatory mechanisms would emerge. This review describes how recent developments have sustained this expectation. The blood-borne factors that control liver regeneration are discussed. Insulin, glucagon, urogastrone, parathyroid hormone, calcitonin, iodothyronines glucocorticoids, gastrointestinal hormones are discussed.