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Haematological changes in hyperimmunized rabbits treated with hydrazinophthalazines for long time periods

Drózdz, M.; Kucharz, E.; Anasz, Z.; Piwowarczyk, B.

Acta Physiologica Polonica 30(5-6): 639-647

1979

ISSN/ISBN: 0044-6033
PMID: 93848
Document Number: 144700
Haematological investigations of peripheral blood and bone marrow were performed in rabbits receiving hydrazinophthalazines (hydralazine or binazin) with or without simultaneous hyperimmunization by means of repeated injections of bovine albumin. It was found that long-term administration of hydralazine caused appearance of LE factor in the serum and LE cells in blood. Less evident changes were caused by Binazin administration. Hyperimmunization caused weaknening of the effects of hydralazinophthalazines. Haematological investigations demonstrated hypochromic anaemia.

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