Correlation between glucocorticoid receptor and cytolytic response of murine lymphoid cell lines
Bourgeois, S.; Newby, R.F.
Cancer Research 39(11): 4749-4751
1979
ISSN/ISBN: 0008-5472 PMID: 498102 Document Number: 144588
By fusion between murine thymoma lines which are either homozygous (r+/r+ or r-/r-) or hemizygous (r+/r-) for the glucocorticoid receptor structural gene r, hybrid clones have been obtained which carry one, two three, or four copies of the r+ allele. These hybrids contain different amounts of normal glucocorticoid receptor as the result of a r+ gene dosage effect. Measurements of the cytolytic response of these hybrids to dexamethasone indicate a tight correlation between receptor content and sensitivity.
Document emailed within 1 workday
Related Documents
Eberlein, T.J.; Rosenstein, M.; Spiess, P.J.; Rosenberg, S.A. 1982: Generation of long-term T-lymphoid cell lines with specific cytotoxic reactivity for a syngeneic murine lymphoma Journal of the National Cancer Institute 69(1): 109-116Salkowski, C.A.; Vogel, S.N. 1992: Lipopolysaccharide increases glucocorticoid receptor expression in murine macrophages. a possible mechanism for glucocorticoid-mediated suppression of endotoxicity Journal of Immunology 149(12): 4041-4047
Conrad, D.H.; Waldschmidt, T.J.; Lee, W.T.; Rao, M.; Keegan, A.D.; Noelle, R.J.; Lynch, R.G.; Kehry, M.R. 1987: Effect of B cell stimulatory factor-1 (interleukin 4) on Fc epsilon and Fc gamma receptor expression on murine B lymphocytes and B cell lines Journal of Immunology 139(7): 2290-2296
Lane, B.C.; Bricker, M.D.; Cooper, S.M. 1982: Fc receptors of mouse cell lines. II. IgG binding specificity and identification of the Fc receptor on a lymphoid leukemia Journal of Immunology 128(4): 1825-1831
Matis, L.A.; Ruscetti, S.K.; Longo, D.L.; Jacobson, S.; Brown, E.J.; Zinn, S.; Kruisbeek, A.M. 1985: Distinct proliferative T cell clonotypes are generated in response to a murine retrovirus-induced syngeneic T cell leukemia: viral gp70 antigen-specific MT4+ clones and Lyt-2+ cytolytic clones which recognize a tumor-specific cell surface antigen Journal of Immunology 135(1): 703-713
Kam, J.C.; Szefler, S.J.; Surs, W.; Sher, E.R.; Leung, D.Y. 1993: Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids Journal of Immunology 151(7): 3460-3466
Picariello, L.; Fiorelli, G.; Martineti, V.; Tognarini, I.; Pampaloni, B.; Tonelli, F.; Brandi, M.Luisa. 2003: Growth response of colon cancer cell lines to selective estrogen receptor modulators Anticancer Research 23(3b): 2419-2424
Burrow, H.M.; Bird, C.C.; Warren, J.V.; Steel, C.M.; Barrett, I.D.; Panesar, N.S. 1981: Human lymphoid cell lines and glucocorticoids: I. Characterization and cytolethal responses of lymphoblastoid, leukaemia and lymphoma lines Diagnostic Histopathology 4(2): 175-188
Tarozzi, A.; Mariani, E.; Facchini, A. 1995: In vitro cytolytic activity of human NK cells against osteosarcoma cell lines Bollettino della Societa Italiana di Biologia Sperimentale 71(7-8): 221-226
Lutz, C.T.; Glasebrook, A.L.; Fitch, F.W. 1981: Alloreactive cloned T cell lines. III. Accessory cell requirements for the growth of cloned cytolytic T lymphocytes Journal of Immunology 126(4): 1404-1408
Tanaka, H.; Akama, H.; Ichikawa, Y.; Makino, I.; Homma, M. 1992: Glucocorticoid receptor in patients with lupus nephritis: relationship between receptor levels in mononuclear leukocytes and effect of glucocorticoid therapy Journal of Rheumatology 19(6): 878-883
Tateno, M. 1987: Rat lymphoid cell lines producing human T cell leukemia virus-i Hokkaido Journal of Medical Science 62(1): 74-81
Jiménez-Clavero, M.A.; González-Rubio, C.; Larrucea, S.; Gamallo, C.; Fontán, G.; López-Trascasa, M. 1995: Cell surface molecules related to factor J in human lymphoid cells and cell lines Journal of Immunology 155(4): 2143-2150
Sengupta, S.; Hibi, T.; Mackay, A.; Markovic, V.; Stein, L.D.; Sigal, N.; Gelfand, E.W.; Chechik, B.E. 1984: Ecto-5'-nucleotidase. I. Expression in human normal and neoplastic lymphoid cell lines representing sequential stages of B-cell differentiation Journal of the National Cancer Institute 73(5): 1075-1080
Waldmann, T.A.; Korsmeyer, S.J.; Greene, W.C. 1986: The arrangement of immunoglobulin, T cell antigen receptor, and interleukin 2 receptor genes in human lymphoid neoplasms Symposium on Fundamental Cancer Research 38: 63-78
McPartland, R.P.; Milholland, R.J.; Morris, H.P.; Rosen, F. 1977: Glucocorticoid receptors in Morris hepatomas and host liver and the correlation of biological activity with receptor levels Cancer Research 37(11): 4160-4165
Rennick, D.; Jackson, J.; Moulds, C.; Lee, F.; Yang, G. 1989: IL-3 and stromal cell-derived factor synergistically stimulate the growth of pre-B cell lines cloned from long-term lymphoid bone marrow cultures Journal of Immunology 142(1): 161-166
Polla, B.S.; Poljak, A.; Ohara, J.; Paul, W.E.; Glimcher, L.H. 1986: Regulation of class Ii gene expression: analysis in B cell stimulatory factor 1-inducible murine pre-B cell lines Journal of Immunology 137(10): 3332-3337
Prystowsky, M.B.; Ely, J.M.; Beller, D.I.; Eisenberg, L.; Goldman, J.; Goldman, M.; Goldwasser, E.; Ihle, J.; Quintans, J.; Remold, H.; Vogel, S.N.; Fitch, F.W. 1982: Alloreactive cloned T cell lines. VI. Multiple lymphokine activities secreted by helper and cytolytic cloned T lymphocytes Journal of Immunology 129(6): 2337-2344
Werner, F.J.; Bornkamm, G.W.; Fleckenstein, B.; Mulder, C. 1978: Episomal viral DNA in herpesvirus saimiri-transformed lymphoid cell lines Iarc Scientific Publications 1978(24 Part 1): 125-130