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Preparation and analysis of new sulfonium derivatives from S-adenosyl (5') -3-methylthiopropylamine

Oliva, A.; Cacciapuoti, G.; Romeo, G.; Porcelli, M.

Bollettino della Societa Italiana di Biologia Sperimentale 55(19): 2019-2024

1979

ISSN/ISBN: 0037-8771
PMID: 554638
Document Number: 144395
The paper reports the preparation and the chromatographic separation of new deaminated analogs of S-adenosyl(5')-3-methylthiopropylamine, i.e. S-adenosyl(5')-3-methylthiopropanol and S-inosyl(5')(-3-methylthiopropanol. These compounds can be used as specific inhibitors of polyamine biosynthesis. It is also reported the characterization of new sulfonium compounds by U.V. spectrophotometry, thin layer chromatography, high voltage electrophoresis, hydrolysis to known fragments.

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