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Preliminary study of the physical chemistry and catalytic properties of glutathione-S-transferase from human placenta

Polidoro, G.; Zulli, P.; Di Ilio, C.; Del Boccio, G.; Di Cola, D.; Federici, G.

Bollettino della Societa Italiana di Biologia Sperimentale 55(9): 840-843

1979

ISSN/ISBN: 0037-8771
PMID: 553608
Document Number: 143591
Glutathione-S-transferase activity has been identified in the cytosol of human placenta. The specific activity measured is about 50% of that found in human liver. While some kinetic data have a close correspondence with those attributed to transferases of other sources, the molecular weight (60.000 daltons) and electric properties of this protein are unusual. The inhibitory effect of several non-substrate compounds suggests that also the placental Glutathione-S-transferase may play some role in detoxication of exogenous substances.

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