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Studies on glutathione of human placenta

Oyake, M.

Nihon Sanka Fujinka Gakkai Zasshi 33(1): 97-106

1981

ISSN/ISBN: 0300-9165
PMID: 7229459
Document Number: 181487
Levels of GSH , and GSH/GSSG ratio in placental tissue from normal, high risk pregnancies and mothers who had light for date infants were investigated. GSH level during normal pregnancy (in mg per 100 g placental tissue) was 16.45 .+-. 5.9 at 1st trimester, 5.60 .+-. 3.4 at 2nd trimester and 18.84 .+-. 5.6 at 3rd trimester. In abortion, GSH level of placenta was .apprx. 1/5 and GSH/GSSG ratio was .apprx. 1/13 those of normal placenta. In the light for date infant, GSH level and GSH/GSSG ratio showed 1/2 the value of average for date infants. GSH level and GSH/GSSG ratio of severe toxemias of pregnancy were higher than those of mild toxemias. In cases of neonatal asphyxia, GSH level and GSH/GSSG ratio were generally lower than those of nonasphyxiated neonate. In the study of subcellular distribution, GSH/GSSG ratio of placental tissue in light for date infant was lower in mitochondria and microsome fractions, and that of placental tissue in toxemias was also lower in microsome and soluble fractions, as compared with those of placental tissue in normal pregnancy.

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