The role of direct tissue contact in the production of gastrointestinal ulcers by anti-inflammatory drugs in rats
Cioli, V.; Putzolu, S.; Rossi, V.; Scorza Barcellona, P.; Corradino, C.
Toxicology and Applied Pharmacology 50(2): 283-289
1979
ISSN/ISBN: 0041-008X PMID: 505458 Document Number: 141856
The role of direct contact and systemic activity of phenylbutazone, indomethacin and ibuprofen in the production of gastrointestinal lesions was studied in the rat comparing the ulcerogenic effects of these drugs after oral and i.v. administration. Phenylbutazone was shown to be more toxic on the stomach than on the intestine, but no differences were observed between the 2 administration routes. Indomethacin was more toxic on the stomach by the oral route than by the i.v. route; the opposite occurred on the intestine. Of the 3 drugs tested, ibuprofen was the only one which proved to be more toxic orally than i.v. both on the stomach and intestine. The anti-inflammatory effects of ibuprofen were equally marked with both routes of administration. The practical implications of these experiments are discussed.