Catechol effect on the lysosomal enzymes in the adipose tissues of obese and obese-diabetic monkeys
Adebonojo, F.O.; Hamilton, C.L.
International Journal of Obesity 3(3): 255-259
1979
ISSN/ISBN: 0307-0565 PMID: 119711 Document Number: 141436
In the adipose tissues of lean normal, obese, and obese-diabetic monkeys, the effect of isoproterenol stimulation on the activities of three lysosomal hydrolases (beta-galactosidase, N-acetyl beta-D-glucosaminidase and acid lipase) were examined. One gram of adipose tissue was obtained from the anterior abdominal wall of 13 adult monkeys (five lean, four obese, four obese-diabetic). The basal activity of acid lipase appeared higher in obese tissues with or without diabetes than in lean tissue; isoproterenol stimulation had no affect. The basal activity of beta-galactosidase was similar in all tissues and unaffected by isoproterenol stimulation. Although basal activity of N-acetyl beta-D-glucosaminidase, otherwise termed hexosaminidase, was comparable in all tissues, activity increased significantly in only the stimulated diabetic-obese tissue.