Adrenal and gonadal function in diabetic obese children with clinical features of moderate feminization
Ciocîrdia, C.; Popa, M.; Florea, I.; Cristoveanu, A.; Tache, A.; Bunea, M.; Chirică, S.
Endocrinologie 17(1): 49-54
1979
ISSN/ISBN: 0253-1801 PMID: 219465 Document Number: 141211
Plasma 17-hydroxycorticosteroids (fluorometrically determined, plasma cortisol), plasma testosterone chorionic gonadotropin (hCG) were performed in all cases. Plasma cortisol had a normal dynamics in all 3 clinical procedures. The mean level of plasma testosterone revealed a significant rise only after hCG. Plasma E2 had a similar pattern of response but in a smaller degree. No significant correlation was found between plasma cortisol and T levels in all procedures. The urinary elimination of testosterone glucuronide and etiocholanolone increased mildly following hCG while androsterone, 11-oxygenated steroids and total estrogens remained unaltered. The adrenal function is apparently not impaired in infantile obesity with decreased glucose tolerance. Plasma T dynamics revealed a peculiar pattern of the immature testis response to hCG and no relation to the adrenal stimulation and suppression. In spite of clinical signs of mild feminization, the basal and the post-hCG levels of E2 were neither abnormally high nor related to the secretory activity.