Effect of the preliminary administration of dextran sulfate on the development of an acute radiation lesion
Zhukova, N.A.; Maksimenko, A.A.
Farmakologiia i Toksikologiia 42(6): 647-650
1979
ISSN/ISBN: 0014-8318 PMID: 499474 Document Number: 140032
Single intraperitoneal administration of dextran sulfate to noninbred mice at a dose of 60 mg/kg 3--24 and 48 hours prior to irradiation in lethal and sublethal doses exerts no radioprotective action. Administration of the drug 24 hours before irradiation increases the intensity of postradiation leukopenia. During irradiation of the animals in a dose of 650 rad dextran sulfate accelerates the recovery of hemopoiesis. With the dose of irradiation being increased up to 750 rad, the drug produces no effect on this parameter.