Induction of interferon production with dextran sulfate
Ershov, F.I.; Moshchik, K.V.; Poverennyĭ, A.M.; Podgorodnichenko, V.K.; Popov, G.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 94(8): 76-77
1982
ISSN/ISBN: 0365-9615 PMID: 6181831 Document Number: 183248
Interferon-inducing activity of polyanions (dextran Sulfate, native DNA, polyphosphate, polypentose, polyanetole sulfate, heparin) was studied. Dextran sulfate applied parenterally and enterally was found to be capable of inducing endogenous interferon production in white mice. The maximal titers of interferon (160 units/ml) were seen in the blood serum of mice upon administering the preparation in a dose of 20 mg/kg body mass. No substantial differences were discovered in the time course of interferon production whatever the route of administration.