Behaviour of drugs under conditions of ultrasonic thermo aerosols
Iwainsky, H.; Sehrt, I.; Lange, A.
Zeitschrift für Erkrankungen der Atmungsorgane 152(2): 164-170
1978
ISSN/ISBN: 0303-657X PMID: 685313 Document Number: 138804
The behaviour os histamine, acetylcholine, mucosolvine, panthenol, prednisolute and dexamethasone is investigated under conditions of thermoaerosol in the USI 50. The concentration of the drug is estimated in the original solution, in the aerosol and in the solution remaining in the nebulizer by means of specific chemical methods. The concentration in the aerosol is nearly unchanged in the case of acetylcholine, panthenol and dexamethasone. In the case of histamine there is only an insignificant decrease. Using prednisolute and dexamethasone the concentration amounts to 86%. Generally the concentration of the solution in the nebulizer increases. Decompositions or alterations of the drugs are not to be seen spectrophotometrically and by means of thin layer chromatography, nor is the pH-value changed. Signs for reactions or interferences with the nebulizer are to be observed in some cases. Therefore regular controls are necessary. In all cases of changing parts of the apparatus the needed material is to be tested concerning its indifference against the drugs used under conditions of thermoaerosol.