The effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response
Albert, N.E.; Sparks, F.C.; Lytton, B.
Investigative Urology 16(2): 134-139
1978
ISSN/ISBN: 0021-0005 PMID: 361626 Document Number: 138729
Bacillus Calmette-Guerín (BCG), Corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. C. parvum and methanol extracted residue of BCG elicited significant immunostimulation without producing irreversible bladder damage. The severe histologic disruption caused by BCG could be reduced by the antituberculus drug isoniazed without abrogating the humoral stimulation. Intramural bladder injection of BCG produced greater humoral stimulation than subcutaneous administration.