Effect of exogenous prostaglandin E2 on different stages in the formation of a humoral immune response
Gromykhina, N.I.; Kozlov, N.A.
Biulleten' Eksperimental'noi Biologii i Meditsiny 93(6): 77-79
1982
ISSN/ISBN: 0365-9615 PMID: 6956373 Document Number: 183728
The influence of exogenous prostaglandin E2 on different stages of the immune response to sheep red blood cells was studied in (CBA x C57BL) F1 mouse hybrids. It was shown that prostaglandin E2 in a dose of 10(-6) M given 72 h after antigen challenge increased the number of the plaque-forming cells. Prostaglandin E2 stimulated antibody formation on being injected to mice in doses 10(-6) M--5 . 10(-4) M 24 and 2 h prior to antigen challenge. Prostaglandin E2 enhanced endogenous colony formation when injected to mice 24 and 2 h prior to sublethal irradiation. It is suggested that prostaglandins regulate different stages of the immune response.