Bacteriological and clinical evaluation of a dicloxacillin-ampicillin combination
Abbate, G.F.; Leonessa, V.; Altucci, P.
Arzneimittel-Forschung 28(6): 1008-1013
1978
ISSN/ISBN: 0004-4172 PMID: 581996 Document Number: 138433
This paper presents the results of the bacteriological and clinical assessment of the dicloxacillin-ampicillin combination Totocillin. The bacteriological examinations show that a synergistic and hyperadditive effect particularly on Staphylococcus, but also on E. coli, Klebsiella-Enterobacter and in a few cases on Proteus spp. is achieved with the combination. Clinical experience in urinary tract infections evidences the good efficacy of the combined preparation, which on statistical evaluation proved to be significantly more active than ampicillin alone. Satisfactory therapeutic results with the combination were yielded also in infections not involving the urinary tract.