Antibody-independent neutralization of vesicular stomatitis virus by human complement. I. Complement requirements

Mills, B.J.; Cooper, N.R.

Journal of Immunology 121(4): 1549-1557

1978


ISSN/ISBN: 0022-1767
PMID: 212482
Document Number: 137869
Normal human serum neutralized up to 5 logs10/ml of vesicular stomatitis virus (VSV) grown in hamster (BHK , which leads to C activation and the sequential deposition of the C components through C3b on the viral envelope. The mechanism of action of the non-Ig serum factor is unknown.

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