Bromocriptine treatment in 2 cases of oligospermia and asthenospermia with normal and excess blood prolactin
Montanari, G.D.; Volpe, A.
Bollettino della Societa Italiana di Biologia Sperimentale 54(18): 1693-1696
1978
ISSN/ISBN: 0037-8771 PMID: 753251 Document Number: 136652
Two male patients with hyperprolactinemia produced a poor grade of sperm. Testicular biopsy in one showed foci of tubular atrophy. Both patients were treated without success with human menopausal gonadotropin (HMG) and arginine, and then with 5 mg bromocryptine/day for 12 wk. Marked improvement was noted in the number and motility of spermatozoa. The 1st patient's wife who was suspected of primary sterility became pregnant on the 10th wk of her husband's treatment schedule. The other man's wife had poor tubal permeability on 1 side and was treated for this by hysterotubal insufflations. The mechanism of bromocryptine action was recently attributed to direct action on dopaminergic receptors at various levels, presumably including the testes in man and the ovary in women. In females it may also inhibit prolactin secreting cells of the pituitary, while stimulating the same gland to produce prolactin inhibiting factor.