Correlation of LH and prolactin pulses in normoprolactinemic women with ovulatory disturbances and variation of LH and FSH pulses and secreting capacity by administration of bromocriptine in the same cases
Kato, K.; Watanabe, R.; Ito, E.; Sakamoto, T.; Morishima, M.; Hoshino, K.; Tanaka, M.; Tadokoro, N.
Nihon Sanka Fujinka Gakkai Zasshi 38(12): 2241-2250
1986
ISSN/ISBN: 0300-9165 PMID: 3100705 Document Number: 285624
1. The difference between prolactin (PRL) basal levels on separate days in the 6 normoprolactinemic women.sbd.one case with an anovular cycle and 5 cases with 1 amenorrhea.sbd.among 14 normoprolactinemic women with ovulatory disturbances, showed significant variation over 13 ng/ml within the normal range of the PRL basal level. 2. PRL pulse frequencies of the same cases from 0900 h. to 1400 h. increased slightly compared with follicular phase. At the same time, the PRL pulse amplitudes were significantly higher than in the follicular phase but significantly lower than the PRL pulse amplitudes in hyperprolactinemic women. 3. The net increase in PRL to TRH in the 6 cases was over 100 ng/ml. When the PRL net increase to TRH was over 100 ng/ml in normoprolactinemic women with ovulatory disturbances, the case is regarded as latent hyperprolactinemia. And 1 or 2 may be latent hyperprolactinemic syndrome. 4. The LH/FSH basal level and .DELTA.LH/.DELTA.FSH to LH/RH before administration of bromocriptine increased in three cases compared with the follicular phase. During the administration of bromocriptine, the ratios decreased and approached the ratio in the follicular phase. The effect of clomid was improved by increased E2 in these cases.