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An analysis on biomedical effects of bipolar electric pulses at different central frequency

Tan, Y.; Yang, H.; Xu, J.; Zhang, Y.; Wu, M.; Zou, H.

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 29(3): 438-442

2012

ISSN/ISBN: 1001-5515
PMID: 22826935
Document Number: 663356
Adopting the cell model of multilayer spherical symmetry and the circuit analysis, the present paper gives the calculated results of the voltages on each of several parts of malignant Tonsillar B-cells and Jurkat T lymphocytes when the first-order Gaussian pulses at different central frequency apposed on them. The relationship between the central frequency and the transmembrane voltages of plasma membrane is also given. The optimum frequency causing electroporation in nuclear envelope is given as well. The paper discusses the reasons of electroporation in membrane and DNA degradation in nuclear. The work provides a reference for usage of transient bipolar electric pulses in cancer treatment.

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