Determination of plasma homocysteine in oligospermia and/or asthenospermia patients
Ge, Y.-F.; Wang, C.-H.; Ouyang, L.-X.; Shao, Y.; Yao, B.; Xia, X.-Y.; Shang, X.-J.; Huang, Y.-F.
Zhonghua Nan Ke Xue 14(12): 1112-1114
2008
ISSN/ISBN: 1009-3591 PMID: 19157234 Document Number: 617127
To detect the level of fasting plasma homocysteine (Hcy) in patients with oligospermia and/or asthenospermia and to investigate its clinical significance. Semen quality analyses and fasting plasma Hcy determination were performed for 86 infertility patients (21 with oligospermia, 32 with asthenospermia and 33 with oligo-asthenospermia) and 19 normal fertile volunteers. The results were compared. The level of plasma Hcy was significantly higher in the infertility patients than in the normal controls (P < 0.05) and negatively correlated with sperm concentration (r = -0.433, P < 0.01), the percentage of grade a sperm (r = -0.303, P < 0.05) and the percentage of grade a+b sperm (r = -0.339, P < 0.01). The increased level of human plasma Hcy directly or indirectly affects spermatogenesis and correlates negatively with oligospermia and/or asthenospermia.