Nature of the ovulation and the state of the preimplantation fetuses in the experimental administration of hormonal and neurotropic agents
Korkhov, V.V.; Nikitin, A.I.; Nikitina, G.V.
Voprosy Okhrany Materinstva i Detstva 23(6): 87-88
1978
ISSN/ISBN: 0042-8825 PMID: 27900 Document Number: 136633
The authors have studied the effects of hormonal and neurotopic agents on ovulation and on the fetus in the preimplantation period. The experiments were done on 100 female rats divided in 5 groups. The 1st group received megestranol in a contraceptive dosage; the 2nd group was administered half of the contraceptive dosage of megestranol; the 3d group received spasmolitin, the 4th a combination of megestranol and spasmolitin, and the 5th group served as a control. Male rats were placed with the females after 2 weeks of treatment. The time of conception was determined by the presence of spermatozoa in vaginal smears. Megestranol was found to increase the quantity of corpus luteum, while the combination of twice as much megestranol with spasmolitin did not have any effect on the corpus luteum. Within 60 hours following the fecundation the fetuses were found in all rats to be in the 2nd-4th stage. The number of normal and degenerated fetuses did not significantly differ from 1 group to the next. In the control group, 5% of the blastocysts showed signs of degeneration; this rate was 23.5% in the rats who were given the combination of spasmolitin and megestranol, and 70% in the rats who received contraceptive dosages of megestranol. These reulsts show that megestranol and combinations of megestranol and spasmolitin affect the ovulation and the development of impregnated ovules.