Effect of heroin, alone and in combination with other substances, on the spontaneous activity and electrocorticogram of the Auguste rat
Filibeck, U.; Castellano, C.
Bollettino della Societa Italiana di Biologia Sperimentale 54(1): 79-85
1978
ISSN/ISBN: 0037-8771 PMID: 737054 Document Number: 136053
A genetic approach to the effect of narcotics on animal behavior was studied using the Auguste rat. These rats belonged to the C57 BL/6J (C57) and DBA/2J (DBA) strains which differ in capacity for learning and activity. Morphine and heroin had opposite effects in these strains. Electrocorticograms were recorded by electrodes implanted in the frontal area. Drug activity was recorded in 2-way cates with an oscillating floor. Heroin in 10 mg/kg doses slowed and synchronized the electrocorticogram (ECG), while amphetamine and strychnine alone had no effects. Amphetamine antagonized the action of heroin. Strychnine was effective at high doses. The effect of heroin on motor activity was diminished mobility. Amphetamine alone stimulated mobility, while strychnine had no effect. Combinations of heroin with strychnine did not antagonize heroin depression, while amphetamine reversed the depressing effect of heroin, provided the latter was given in a reduced dose (5 mg/kg).