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Formation of DNA--protein crosslinks and their possible elimination in cultures of normal human fibroblasts after exposure to embichin

Rupasov, V.V.; Kukharenko, V.I.; Gorin, A.I.; Grinberg, K.N.; Tseĭtlin, P.I.

Biulleten' Eksperimental'noi Biologii i Meditsiny 86(9): 365-367

1978

ISSN/ISBN: 0365-9615
PMID: 698384
Document Number: 135779
New methods of radiometry and fractionation of cell lysates on hydroxyapatite were applied to determine the crosslinkage between DNA and protein induced by embiquin in cell culture of normal human skin fibroblasts. Such crosslinks were found to be formed; they were eliminated in long-term cultivation of the cells after mutagen treatment.

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