3,4,5-Trimethoxybenzoic acid, a new mescaline metabolite in humans
Demisch, L.; Kaczmarczyk, P.; Seiler, N.
Drug Metabolism and Disposition the Biological Fate of Chemicals 6(5): 507-509
1978
ISSN/ISBN: 0090-9556 PMID: 30599 Document Number: 135403
After ingestion of 400 mg of mescaline sulfate by human volunteers, 3,4,5-trimethoxybenzoic acid was isolated from urine and identified by gas chromatography-mass spectrometry. The amount of this anionic mescaline metabolite was found to be very low as compared with that of the well-konwn 3,4,5-trimethoxyphenylacetic acid. The significance of this finding is discussed.
Document emailed within 1 workday
Related Documents
Glinka, R.; Mikołajewska, H.; Szadowska, A.; Kiełek, M. 1985: Synthesis and the study of the effect of new 3,4,5-trimethoxybenzoic acid derivatives on the central nervous system Acta Poloniae Pharmaceutica 42(2): 117-122Dyer, D.C.; Benington, F.; Morin, R.D. 1975: Antagonism of d-lysergic acid diethylamide and mescaline by 1-methyl-1, 2, 5, 6-tetrahydropyridine-N, N-diethyl-carboxamide (THPC) Archives Internationales de Pharmacodynamie et de Therapie 217(2): 197-200
Mukherjee, A.; Dey, P.K.; Dixit, S.N.; Khosa, R.L. 1971: Effect of mescaline on glutamic acid decarboxylase and gaba-oxoglutarate transferase activities of rat brain Indian Journal of Experimental Biology 9(1): 10-12
Speck, U.; Mützel, W.; Kolb, K.H.; Acksteiner, B.; Schulze, P.E. 1974: Pharmacokinetics and metabolite spectrum of glisoxepide in humans Arzneimittel-Forschung 24: 404-409
Greter, J.; Lindstedt, S.; Steen, G. 1983: 2,6-Dimethyloctanedioic acid--a metabolite of phytanic acid in Refsum's disease Clinical Chemistry 29(3): 434-437
Porubek, D.J.; Grillo, M.P.; Baillie, T.A. 1989: The covalent binding to protein of valproic acid and its hepatotoxic metabolite, 2-n-propyl-4-pentenoic acid, in rats and in isolated rat hepatocytes Drug Metabolism and Disposition: the Biological Fate of Chemicals 17(2): 123-130
Moch, D.; Schewe, T.; Kühn, H.; Schmidt, D.; Buntrock, P. 1990: The linoleic acid metabolite 9DS-hydroxy-10,12(E,Z)-octadecadienoic acid is a strong proinflammatory mediator in an experimental wound healing model of the rat Biomedica Biochimica Acta 49(4): 201-207
Winter, J.C. 1971: Tolerance to a behavioral effect of lysergic acid diethylamide and cross-tolerance to mescaline in the rat: absence of a metabolic component Journal of Pharmacology and Experimental Therapeutics 178(3): 625-630
Teunissen, M.W.; De Leede, L.G.; Boeijinga, J.K.; Breimer, D.D. 1985: Correlation between antipyrine metabolite formation and theophylline metabolism in humans after simultaneous single-dose administration and at steady state Journal of Pharmacology and Experimental Therapeutics 233(3): 770-775
Lennernäs, H.; Renberg, L.; Hoffmann, K.J.; Regårdh, C.G. 1993: Presystemic elimination of the beta-blocker pafenolol in the rat after oral and intraperitoneal administration and identification of a main metabolite in both rats and humans Drug Metabolism and Disposition: the Biological Fate of Chemicals 21(3): 435-440
D'Ancona, S.; Magnolfi, G.; Guidetti, G.; Toffoli, G.; Lazzarini, A.; Carrara, M.; Magon, M.; Luciani, S.; Berti, T. 1986: Effects of 6,6'-dithiodinicotinic acid (CPDS) and its metabolite 6-mercaptonicotinic acid (6-MNA) on murine and hamster fibroblasts (3T3 and BHK) and murine metastatic melanoma cells (F10) Chemioterapia: International Journal of the Mediterranean Society of ChemoTherapy 5(4): 219-227
May, D.G.; Naukam, R.J.; Kambam, J.R.; Branch, R.A. 1992: Cimetidine-carbaryl interaction in humans: evidence for an active metabolite of carbaryl Journal of Pharmacology and Experimental Therapeutics 262(3): 1057-1061
Vane, F.M.; Buggé, C.J. 1981: Identification of 4-oxo-13-cis-retinoic acid as the major metabolite of 13-cis-retinoic acid in human blood Drug Metabolism and Disposition: the Biological Fate of Chemicals 9(6): 515-520
Jenss, H.; Weber, P.; Hartmann, F. 1990: 5-Aminosalicylic acid and its metabolite in breast milk during lactation American Journal of Gastroenterology 85(3): 331
Yokoyama, A.; Takakubo, F.; Eto, K.; Ueno, K.; Igarashi, T.; Satoh, T.; Kitagawa, H. 1984: Teratogenicity of aspirin and its metabolite, salicylic acid, in cultured rat embryos Research Communications in Chemical Pathology and Pharmacology 46(1): 77-91
Cazzulani, P.; Pietra, C.; Abbiati, G.A.; Ceserani, R.; Oliva, D.; Civelli, M.; Tajana, A.; Nardi, D. 1988: Pharmacological activities of the main metabolite of flavoxate 3-methylflavone-8-carboxylic acid Arzneimittel-Forschung 38(3): 379-382
Corpet, D.E.; Bories, G.F. 1987: 3H]chloramphenicol metabolism in human volunteer: oxamic acid as a new major metabolite Drug Metabolism and Disposition: the Biological Fate of Chemicals 15(6): 925-927
Pieniaszek, H.J.; BatesTR 1975: Colorimetric determination of 5-aminosalicylic acid and its N-acetylated metabolite on urine and feces Research Communications in Chemical Pathology and Pharmacology 12(3): 571-581
Schlossmann, K.; Pütter, J. 1973: Studies on the formation of the lactone and acid form of the main metabolite of mefruside Arzneimittel-Forschung 23(2): 255-262
Claeys, M.; Wechsung, E.; Herman, A.G.; Nugteren, D.H. 1981: Prostaglandin E2 is the prevalent metabolite of arachidonic acid formed by aortic tissue of the chicken Archives Internationales de Pharmacodynamie et de Therapie 249(2): 312-315