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Antagonism of d-lysergic acid diethylamide and mescaline by 1-methyl-1, 2, 5, 6-tetrahydropyridine-N, N-diethyl-carboxamide (THPC)

Dyer, D.C.; Benington, F.; Morin, R.D.

Archives Internationales de Pharmacodynamie et de Therapie 217(2): 197-200

1975

ISSN/ISBN: 0003-9780
PMID: 127560
Document Number: 84395
Contractions of sheep umbilical vasculature induced by 5-hydroxytryptamine, mescaline and d-lysergic acid diethylamide (LSD) were antagonized by 1-methyl-1, 2, 5, 6-tetrahydropyridine-N, N-diethyl-carboxamide (THPC) 5 X 10(-4)M. THPC did not block contractile responses to angiotensin. The data are interpreted to support our previous suggestions that certain chemical entities representing portions of the LSD molecule may be effectively studied as antagonists to the hallucinogens. The present data indicate that THPC is a weak 5-hydroxytryptamine receptor antagonist.

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Winter, J.C. 1971: Tolerance to a behavioral effect of lysergic acid diethylamide and cross-tolerance to mescaline in the rat: absence of a metabolic component Journal of Pharmacology and Experimental Therapeutics 178(3): 625-630
Harvey, J.A.; Gormezano, I.; Cool, V.A. 1982: Effects of d-lysergic acid diethylamide, d-2-bromolysergic acid diethylamide, dl-2,5-dimethoxy-4-methylamphetamine and d-amphetamine on classical conditioning of the rabbit nictitating membrane response Journal of Pharmacology and Experimental Therapeutics 221(2): 289-294
Kocur, J. 1975: Some psychotoxicological problems exemplified by lysergic acid diethylamide Wiadomosci Lekarskie 28(5): 383-386
Sam, V.; Joseph, T. 1973: Effect of lysergic acid diethylamide on oestrus cycle and offspring in rats Indian Journal of Physiology and Pharmacology 17(3): 277-282
Kilmer, S.D. 1994: The isolation and identification of lysergic acid diethylamide (LSD) from sugar cubes and a liquid substrate Journal of Forensic Sciences 39(3): 860-862
Bell, J.A.; Martin, W.R. 1974: Studies of tryptamine and lysergic acid diethylamide (LSD) on cutaneous C-fiber and polysynaptic reflexes in the cat Journal of Pharmacology and Experimental Therapeutics 190(3): 492-500
Burt, D.R.; Creese, I.; Snyder, S.H. 1976: Binding interactions of lysergic acid diethylamide and related agents with dopamine receptors in the brain Molecular Pharmacology 12(4): 631-638
Burris, K.D.; Breeding, M.; Sanders-Bush, E. 1991: (+)Lysergic acid diethylamide, but not its nonhallucinogenic congeners, is a potent serotonin 5HT1C receptor agonist Journal of Pharmacology and Experimental Therapeutics 258(3): 891-896
Dwoskin, L.P.; Sparber, S.B. 1983: Behaviorally inactive doses of mianserin antagonize the suppressant effect of lysergic acid diethylamide on a fixed-ratio operant Journal of Pharmacology and Experimental Therapeutics 225(1): 77-84
Harik, S.I.; Schmidley, J.W.; Iacofano, L.A.; Blue, P.; Arora, P.K.; Sayre, L.M. 1987: On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: the effect of perinigral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite and their analogs in the rat Journal of Pharmacology and Experimental Therapeutics 241(2): 669-676
Keshavarzian, A.; Haydek, J.M.; Zepeda, D.O.; Stinneford, J.G.; Fields, J.Z. 1990: Gastroduodenal ulcers in rats induced by 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP): requirement for gastric acid secretion and the role of prostaglandins Research Communications in Chemical Pathology and Pharmacology 70(1): 21-48
Riachi, N.J.; LaManna, J.C.; Harik, S.I. 1989: Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain Journal of Pharmacology and Experimental Therapeutics 249(3): 744-748
Kindt, M.V.; Heikkila, R.E.; Nicklas, W.J. 1987: Mitochondrial and metabolic toxicity of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine Journal of Pharmacology and Experimental Therapeutics 242(3): 858-863
Jenner, P.; Marsden, C.D. 1986: The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease Journal of Neural Transmission. Supplementum 20: 11-39
Di Monte, D.A.; Wu, E.Y.; Delanney, L.E.; Irwin, I.; Langston, J.W. 1992: Toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in primary cultures of mouse astrocytes Journal of Pharmacology and Experimental Therapeutics 261(1): 44-49
Kryzhanovskiĭ, G.N.; Atadzhanov, M.A.; Zagorevskiĭ, V.A.; Sharkova, L.M.; Voronina, T.A. 1988: Experimental parkinsonian syndrome in rats induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Biulleten' Eksperimental'noi Biologii i Meditsiny 105(4): 397-401
Shahi, G.S.; Moochhala, S.M.; Das, N.P.; Sunamoto, J.; Tajima, K. 1990: The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces changes in the heme spin state of microsomal cytochrome P-450 Biochemistry International 22(5): 895-901
Gugutsidze, D.A.; Nerobkova, L.N.; Boronina, T.A. 1989: Analysis of sleep-wakefulness structure in parkinsonian syndrome in rats induced by 1-methyl-4-phenyl-1,2,2,6-tetrahydropyridine and oxotremorine Biulleten' Eksperimental'noi Biologii i Meditsiny 108(8): 206-209
Sattler, H.J.; Schunack, W.; Rochelmeyer, H. 1974: Structure-activity relationship of analeptics of the nicethamide type. 1. Diethylamide of homologous and vinylogs of nicotinic acid and isonicotinic acid Arzneimittel-Forschung 24(5): 743-746
Chen, S. 1990: Experimental research on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian animal models in the rhesus monkey and C57 black mouse Zhonghua Yi Xue Za Zhi 70(5): 252-254; 18