Enzymatic activity in the uterine musculature of rats after castration and testosterone treatment
Zherev, S.; Popova, N.
Eksperimentalna Meditsina i Morfologiia 17(4): 187-190
1978
ISSN/ISBN: 0367-0643 PMID: 729526 Document Number: 134033
The authors examined the activity of GOT, GPT, LDH and ALD in the myometrium of ovariectomized female rats, treated with testosterone. There was a eduction in the activity of the examined enzymes in both experimental groups of animals in comparison with the group of healthy rats. The reduction of the enzymic myometrial activity was considerably more manifested in the group of ovariectomized rats than in those treated with testosterone. The results were interpreted as a consequence of the reduced synthesis of proteins enzymes due to insufficient estrogen stimulation in the myometrial tissue, sensitive to estrogen. There was a possibility also that the reduction of the enzymic synthesis was caused by energetic deficit on account of insufficient transhydrogenase activity as a result of the reduced estrogen concentrations.