Fever, rash, and muscle tenderness. A distinctive clinical presentation of disseminated candidiasis
Jarowski, C.I.; Fialk, M.A.; Murray, H.W.; Gottlieb, G.J.; Coleman, M.; Steinberg, C.R.; Silver, R.T.
Archives of Internal Medicine 138(4): 544-546
1978
ISSN/ISBN: 0003-9926 PMID: 637635 Document Number: 133988
Five patients had fatal, disseminated candidiasis. At the onset of candidemia, a remarkably similar and distinctive triad of high fever, papular erythematous skin lesions, and diffuse severe muscle tenderness developed in each patient. This previously unreported clinical syndrome is sufficiently unique to justify a presumptive diagnosis of disseminated candidiasis and the use of empiric antifungal therapy pending culture and biopsy results.