Antihypertensive effects of delta9-tetrahydrocannabinol
Kosersky, D.S.
Archives Internationales de Pharmacodynamie et de Therapie 233(1): 76-81
1978
ISSN/ISBN: 0003-9780 PMID: 686909 Document Number: 133854
Repeated oral administration of delta9-tetrahydrocannabinol (delta9-THC, 25 mg/kg) reduced systolic blood pressure in conscious spontaneously hypertensive rats. Tolerance to the antihypertensive actions of delta9-THC failed to develop during the 10-day treatment period. The failure of delta9-THC to alter blood pressure in normotensive rats suggests that the hypotensive action of delta9-THC is dependent, in part, on baseline blood pressure.
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