Pharmacokinetics of butocine
Grafnetterová, J.; Smahel, O.; König, J.; Matl, I.
Neoplasma 25(2): 203-209
1978
ISSN/ISBN: 0028-2685 PMID: 643124 Document Number: 132663
The pharmacokinetics of Butocine (glycine, N-[1-oxo-5-(1H-purin-6-ylthio)pentyl], ethyl ester) was studied in 8 individuals with malignant tumor after a single oral dose of 500 mg. Butocine is quickly absorbed from the alimentary tract. Highest serum levels were found 45 minutes after administration. Its urinary excretion is very low (2.5 per cent in 15 hours), 1.7 per cent being eliminated 3 hours after administration. Its renal clearance is likwise very low, i.e. 1.5 ml/min compared with endogenous creatinine clearance of 81.2 ml/min.