Pharmacokinetics of PTT-119 in man
Pannuti, F.; Coppi, G.; Borella, F.; Martoni, A.; Urbano, L.; Melotti, B.
Chemioterapia International Journal of the Mediterranean Society of ChemoTherapy 7(2): 113-116
1988
ISSN/ISBN: 0392-906X PMID: 3396115 Document Number: 314033
The pharmacokinetics of PTT-119, a new alkylating agent, was studied in 8 advanced cancer patients. PTT-119 disappeared rapidly from plasma after administration at a dose of 3 mg/kg by i.v. bolus injection. The HPLC method shows plasma levels of m-bis (dichloroethyl)amino-phenyl-L-alanine which is the major metabolite of PPT-119. Elimination of the drug from plasma can be described by a one-compartment model. Mean values of 77.8 min for the half-life, 510.8 ml/min for the total plasma clearance and 0.69 l/kg for the volume of distribution were found.