The effect of pesticide combinations in laboratory rats. III. Modification of selected enzymes
Golbs, S.; Fuchs, V.; Leipner, E.; Hüttel, I.
Archiv für Experimentelle Veterinarmedizin 32(4): 569-577
1978
ISSN/ISBN: 0003-9055 PMID: 83128 Document Number: 130474
After oral administration of pesticides Parathion-methyl, Carbaryl, Lindane and their combinations were investigated the activities of enzyme SGOT, SGPT, Alkaline Phosphatase and Cholinesterase. Results concerning SGOT-activity demonstrated a significant increase in all groups. The cause of this rise can be found in its effect on liver, muscle and/or heart. The activity of cholinesterase is significantly lower in the combinations of Parathion-methyl/Lindane, Lindane/Carbaryl and Carbaryl/Parathion-methyl. In future the extent of these investigations concerning the subacute toxicity, chronical toxicity, the additive or cumulative effects of pesticide--combinations, combinations of pesticides with drugs and/or xenobiotics etc. must be enhanced in any case.