Endometrial stromal sarcoma arising from vaginal endometriosis
Berkowitz, R.S.; Ehrmann, R.L.; Knapp, R.C.
Obstetrics and Gynecology 51(1 Suppl): 34s-37s
1978
ISSN/ISBN: 0029-7844 PMID: 618472 Document Number: 129522
The present case reports the concurrence of endometriosis of the vaginal cuff with endometrial stromal sarcoma in association with high-dose estrogen. This case raises the question of whether chronic high-dose estrogen might be associated with malignant transformation of human endometrial stroma. Although there is no definitive evidence of a causal relation between estrogen and endometrial stromal sarcoma, the possibility should be explored further. Therapy of this neoplasm is discussed and salient clinical and pathologic features are reviewed.