The effect of hexose monophosphate shunt inhibitors on adenohypophyseal and ceruloplasmin reactions to oestrogen
Schreiber, V.; Pribyl, T.
Physiologia Bohemoslovaca 27(4): 301-307
1978
ISSN/ISBN: 0369-9463 PMID: 151286 Document Number: 127962
Estradiol benzoate, as an aqueous microcrystal suspension, was administered i.m. to rats in doses of 1 mg 2 times/week. It induced adenohypophyseal hyperplasia and increased thyroxine-binding capacity of adenohypophyseal proteins in vitro and raised blood ceruloplasmin level. The simultaneous administration of a hexose monophosphate shunt inhibitor .sbd. 6-aminonicotinamide [200 .mu.g/rat per day in food] or oxythiamine [8 mg/rat per day in food] .sbd. did not modify the reaction of the adenohypophysis. The hexose monophosphate shunt probably did not play a significant role in the adenohypophyseal reaction to estrogens. By themselves, both inhibitors raised the blood ceruloplasmin level and their effect summated with that of estradiol. The mechanism of action of the inhibitors is not known, but a nonspecific stress effect leading to an increase in the ceruloplasmin level as an acute phase protein is considered to be most likely. The estrogenized adenohypophysis may be transformed to tumor tissue, 1st of the character of an adenoma, but later of a metastasizing carcinoma. Studies of adenohypophyseal reactions to estrogens are one of the possible ways of studying the initial phases of carcinogenesis.